- Real-time reaction tracking
- Eradicated sampling
- Provided framework for pilot phase scale up
A North American research division faced major challenges in measuring oligosaccharides during synthesis reactions. The problems stemmed from the time-consuming nature of offline HPLC molecular weight measurements, which took 4 hours to yield results. This was hindering the scale-up process from laboratory to pilot phase.
The researchers identified a need for a reproducible inline solution that could track the reaction in real-time. A ReactaVisc was introduced to the process and the results were evaluated across multiple reactions.
The ReactaVisc was able to accurately track viscosity vs temperature, and produce a repeatable, stable trace, even amongst the bubbling reaction. Due to the challenging nature of the reaction this feature was particularly important.
The researchers also found the inline readings correlated perfectly with offline molecular weight (Mw) values and established a cubic relationship between viscosity and Mw with an R-squared value of 0.95.
The introduction of real-time monitoring allows for quicker decisions and adjustments during the reaction, which has streamlined the research and development process, and provided the necessary framework for scale-up to pilot phase.